abstract：:Diesel exhaust particles (DEP) are known to modulate the production of cytokines associated with acute and chronic respiratory symptoms and allergic respiratory disease. Tolerance is an important mechanism through which the immune system can maintain nonresponsiveness to common environmental antigens. We examined the ...

journal_title：Clinical and experimental immunology

authors： Pacheco KA,Tarkowski M,Sterritt C,Negri J,Rosenwasser LJ,Borish L

更新日期：2001-12-01 00:00:00

abstract：:The expression of melanocortin MC(1) receptors on human peripheral lymphocyte subsets was analysed by flow cytometry using rabbit antibodies selective for the human MC(1) receptor and a panel of monoclonal antibodies against lymphocyte differentiation markers. The MC(1) receptor was found to be constitutively expresse...

journal_title：Clinical and experimental immunology

authors： Neumann Andersen G,Nagaeva O,Mandrika I,Petrovska R,Muceniece R,Mincheva-Nilsson L,Wikberg JE

更新日期：2001-12-01 00:00:00

abstract：:We report a case of a combined immunodeficiency (CID) in a child affected by trichothiodystrophy (TTD) characterized by an altered response to ultraviolet (UV) light due to a defect in the XPD gene. The XPD gene encodes a subunit of the transcription factor II H (TFIIH), a complex involved in nucleotide-excision repai...

journal_title：Clinical and experimental immunology

authors： Racioppi L,Cancrini C,Romiti ML,Angelini F,Di Cesare S,Bertini E,Livadiotti S,Gambarara MG,Matarese G,Lago Paz F,Stefanini M,Rossi P

更新日期：2001-12-01 00:00:00

abstract：:In ANCA-associated vasculitis the activation of primed leucocytes by autoantibodies with subsequent release of proteases such as myeloperoxidase (MPO), proteinase 3 (PR3) and elastase is thought to play an important pathogenetic role. Whether these proteases contribute to the vascular lesions by stimulating the procoa...

journal_title：Clinical and experimental immunology

authors： Haubitz M,Gerlach M,Kruse HJ,Brunkhorst R

更新日期：2001-12-01 00:00:00

abstract：:This study was performed to determine whether or not IL-18, formerly called IFN-gamma-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with allergic bronchial asthma (BA), patients with atopic dermatitis (AD) and controls who ...

journal_title：Clinical and experimental immunology

authors： El-Mezzein RE,Matsumoto T,Nomiyama H,Miike T

更新日期：2001-11-01 00:00:00

abstract：:To elucidate the in vivo mechanisms involved in the impairment in pulmonary defence as the result of treatment with glucocorticoids, we established fatal pneumonia with bacteraemia in dexamethasone (DEX)-treated mice by means of an intratracheal challenge of Pseudomonas aeruginosa. An increased neutrophil influx was o...

journal_title：Clinical and experimental immunology

authors： Satoh S,Oishi K,Iwagaki A,Senba M,Akaike T,Akiyama M,Mukaida N,Atsushima KM,Nagatake T

更新日期：2001-11-01 00:00:00

abstract：:New antibodies against a U3 snRNP, which were named anti-Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, ...

journal_title：Clinical and experimental immunology

authors： Kubo M,Ihn H,Kuwana M,Yamane K,Yazawa N,Tamaki K

更新日期：2001-11-01 00:00:00

abstract：:Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here ...

journal_title：Clinical and experimental immunology

authors： Abe M,Shintani Y,Eto Y,Harada K,Fujinaka Y,Kosaka M,Matsumoto T

更新日期：2001-10-01 00:00:00

abstract：:There are few studies assessing the pathogenicity of human monoclonal anti-DNA antibodies. The use of SCID mice avoids the problem of rejection of the human hybridoma cells thus allowing in vivo assessment of human immunoglobulins. Using electron microscopy we have shown that the human IgG anti-dsDNA monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Mason LJ,Ravirajan CT,Latchman DS,Isenberg DA

更新日期：2001-10-01 00:00:00

abstract：:Transfer of contact sensitivity (CS) responses by immune lymphoid cells was the first finding that distinguished cellular from humoral immunity. CS has remained the most studied T cell reaction in vivo, and is the prototype for a variety of delayed-type hypersensitivity (DTH) responses. DTH in essence is the recruitme...

journal_title：Clinical and experimental immunology

authors： Askenase PW

更新日期：2001-09-01 00:00:00

abstract：:In general, exogenous proteins are processed by antigen-presenting cells in the endosomes for major histocompatibility complex (MHC) class II presentation to CD4+ T cells, while proteins synthesized endogenously are processed in the cytoplasm for MHC class I presentation to CD8+ T cells. However, it is recognized that...

journal_title：Clinical and experimental immunology

authors： Voeten JT,Rimmelzwaan GF,Nieuwkoop NJ,Fouchier RA,Osterhaus AD

更新日期：2001-09-01 00:00:00

abstract：:Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti-inflammatory properties, apparently mediated by the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). To determine the mechanisms by which dietary EPA and DHA modulate mouse T-cell...

journal_title：Clinical and experimental immunology

authors： Arrington JL,Chapkin RS,Switzer KC,Morris JS,McMurray DN

更新日期：2001-09-01 00:00:00

abstract：:In susceptible mice, the heavy metal ion mercury is able to induce a strong immune activation, which resembles a T helper 2 (Th2) type of immune response and is characterized by a polyclonal B cell activation, formation of high levels of IgG1 and IgE antibodies, production of autoantibodies of different specificities ...

journal_title：Clinical and experimental immunology

authors： Brenden N,Rabbani H,Abedi-Valugerdi M

更新日期：2001-08-01 00:00:00

abstract：:In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

journal_title：Clinical and experimental immunology

authors： Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

更新日期：2001-08-01 00:00:00

abstract：:Blood monocytes of patients with thyroid autoimmune disease (TAID) display defects in rearranging their cortical actomyosin cytoskeleton ('polarize') in response to chemoattractants. Such rearrangements also take place after the adherence of monocytes to the extracellular matrix (ECM). It is therefore not surprising t...

journal_title：Clinical and experimental immunology

authors： Canning MO,Grotenhuis K,De Haan-Meulman M,De Wit HJ,Berghout A,Drexhage HA

更新日期：2001-07-01 00:00:00

abstract：:Schizophrenic patients are reported to have immunological dysfunction, however, the immune response to surgery in schizophrenic patients remains unclear. We measured plasma interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) before, during and after colectomy, hemicolectomy and sigm...

journal_title：Clinical and experimental immunology

authors： Kudoh A,Sakai T,Ishihara H,Matsuki A

更新日期：2001-07-01 00:00:00

abstract：:Ro ribonucleoproteins (RNPs) are autoantigens that result from the association of a 60-kDa protein (Ro60) with a small RNA (hY1, hY3, hY4 or hY5 in humans, mY1 or mY3 in mice). Previous studies localized Ro RNPs to the cytoplasm. Because Ro RNPs containing hY5 RNA (Ro(hY5) RNPs) have unique biochemical and immunologic...

journal_title：Clinical and experimental immunology

authors： Gendron M,Roberge D,Boire G

更新日期：2001-07-01 00:00:00

abstract：:Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations t...

journal_title：Clinical and experimental immunology

authors： Gouttefangeas C,Eberle M,Ruck P,Stark M,Müller JE,Becker HD,Rammensee HG,Pinocy J

更新日期：2001-06-01 00:00:00

abstract：:Antilactoferrin antibodies have been reported in patients with several autoimmune disorders, including primary biliary cirrhosis, autoimmune hepatitis and autoimmune cholangitis. We investigated the prevalence and the clinical significance of such autoreactivity in patients with autoimmune and viral chronic liver dise...

journal_title：Clinical and experimental immunology

authors： Muratori L,Muratori P,Zauli D,Grassi A,Pappas G,Rodrigo L,Cassani F,Lenzi M,Bianchi FB

更新日期：2001-06-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an e...

journal_title：Clinical and experimental immunology

authors： Gonçalves AS,Appelberg R

更新日期：2001-05-01 00:00:00

abstract：:The proliferative response of preparations of whole PBMC populations from 20 healthy individuals and 28 multiple sclerosis (MS) patients to purified protein derivative (PPD) and myelin basic protein (MBP) was monitored in a kinetic assay over a period of up to 10 days. PPD produced a classical secondary response in bo...

journal_title：Clinical and experimental immunology

authors： Ponsford M,Mazza G,Coad J,Campbell MJ,Zajicek J,Wraith DC

更新日期：2001-05-01 00:00:00

abstract：:Previous findings have indicated that the major surface molecule of Leishmania, lipophosphoglycan (LPG), could abrogate HIV-1-induced syncytium formation and virus replication. In the present work, we were interested in characterizing this inhibitory process. Data from a new luciferase-based semiquantitative assay for...

journal_title：Clinical and experimental immunology

authors： Genois N,Barbeau B,Olivier M,Tremblay MJ

更新日期：2001-04-01 00:00:00

abstract：:IL-10 and IL-12 are cytokines which are important in regulating immune responses. Plasma levels of IL-10 and autoantibodies against double-stranded DNA (dsDNA) often mirror disease activity in patients with SLE. IL-12 secretion from SLE patients' blood mononuclear cells also correlates with disease activity, but has a...

journal_title：Clinical and experimental immunology

authors： Tyrrell-Price J,Lydyard PM,Isenberg DA

更新日期：2001-04-01 00:00:00

abstract：:Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate mode...

journal_title：Clinical and experimental immunology

authors： Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TM

更新日期：2001-03-01 00:00:00

abstract：:The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was...

journal_title：Clinical and experimental immunology

authors： Tsuyuguchi K,Suzuki K,Matsumoto H,Tanaka E,Amitani R,Kuze F

更新日期：2001-03-01 00:00:00

abstract：:IL-1 acts on many cells as an inflammatory mediator. Its two forms, IL-1 alpha and IL-1 beta, are regulated differentially within hyperproliferative inflammatory skin conditions, such as psoriasis. While IL-1 alpha is down-regulated within psoriatic lesions, the levels of IL-1 beta are increased. However, some investi...

journal_title：Clinical and experimental immunology

authors： Schön M,Behmenburg C,Denzer D,Schön MP

更新日期：2001-03-01 00:00:00

abstract：:Cachexia is one of the prominent features of advanced tuberculosis (TB) seen in association with increased expression of the monokine TNF-alpha. Several mycobacterial proteins, including PPD, stimulate TNF-alpha secretion from monocytes. Host factors that may play a role in cytokine expression from monocytes remain la...

journal_title：Clinical and experimental immunology

authors： Hussain R,Shiratsuchi H,Phillips M,Ellner J,Wallis RS

更新日期：2001-02-01 00:00:00

abstract：:We studied the relationship between the HLA specificities associated with multiple sclerosis (MS) susceptibility in southern Italy and the reactivity of the human myelin basic protein (hMBP) immunogenic peptides 84-98 and 143-168, using short-term T-cell lines established from 9 MS patients and from 8 healthy individu...

journal_title：Clinical and experimental immunology

authors： Montanaro D,Sanna V,Matarese G,Larby BB,Racioppi L,Carrieri PB,Bruno R,Davey NJ,Zappacosta S,Fontana S

更新日期：2001-02-01 00:00:00

abstract：:To formulate a 'logic' for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the germ-line human V3-23 gene, multiple diversity (D) and joining (J) gene segments. Hybridomas p...

journal_title：Clinical and experimental immunology

authors： Mageed RA,Harmer IJ,Wynn SL,Moyes SP,Maziak BB,Brüggemann M,MacKworth-Young CG

更新日期：2001-01-01 00:00:00

abstract：:The role of HLA-A*6802-restricted CD8+ T cells in chlamydial disease was investigated in human ocular infections. Peptides with predicted binding motifs for HLA-A*6802 were synthesized using sequences based on chlamydial antigens, major outer membrane protein (MOMP), macrophage infectivity potentiator (MIP) and heat s...

journal_title：Clinical and experimental immunology

authors： Mahdi OS,Whittle HC,Joof H,Mabey DC,Bailey RL

更新日期：2001-01-01 00:00:00

abstract：:The aim of the present study was to investigate the prevalence of C4 and C2 deficiencies and to characterize genomic alterations in C4 genes in a large cohort of 125 unselected patients with SLE. We determined the protein concentration and functional activity of C2 and C4, as well as the C4 phenotype. C4 genotyping in...

journal_title：Clinical and experimental immunology

authors： Dragon-Durey MA,Rougier N,Clauvel JP,Caillat-Zucman S,Remy P,Guillevin L,Liote F,Blouin J,Ariey F,Lambert BU,Kazatchkine MD,Weiss L

更新日期：2001-01-01 00:00:00

abstract：:Immune parameters were compared in four groups of Ugandan subjects: HIV-and HIV+ adult patients with active pulmonary TB (HIV- PTB n = 38; HIV+ PTB n = 28), patients with HIV infection only (n = 26) and PPD+ healthy controls (n = 25). Compared with healthy controls, CD4 and CD8 T cells from patients with HIV and/or PT...

journal_title：Clinical and experimental immunology

authors： Hertoghe T,Wajja A,Ntambi L,Okwera A,Aziz MA,Hirsch C,Johnson J,Toossi Z,Mugerwa R,Mugyenyi P,Colebunders R,Ellner J,Vanham G

更新日期：2000-12-01 00:00:00

abstract：:It is unclear how breakdown in immune tolerance to the ubiquitous self-antigen pyruvate dehydrogenase complex (PDC), seen in the autoimmune liver disease PBC, gives rise to tissue damage with such a limited distribution (restricted to the liver and salivary and lachrymal glands). One property shared by these tissues i...

journal_title：Clinical and experimental immunology

authors： Palmer JM,Doshi M,Kirby JA,Yeaman SJ,Bassendine MF,Jones DE

更新日期：2000-12-01 00:00:00

abstract：:Autoantibodies to EEA1 have been described in patients with neurological diseases, subacute cutaneous lupus and a variety of other conditions, including a patient with Wegener's granulomatosis (WG). EEA1 is a hydrophilic peripheral membrane protein transiently associated with the cytoplasmic face of early endosomes. A...

journal_title：Clinical and experimental immunology

authors： Selak S,Woodman RC,Fritzler MJ

更新日期：2000-12-01 00:00:00

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:Dendritic cells (DCs) were prepared from human bronchoalveolar lavage (BAL) cells. We previously reported that, in particular, the CD1a fraction of the low autofluorescent (LAF) cells contains the precursors for DCs: after overnight culture, 40% of the LAF cells change into functionally and phenotypically prototypic d...

journal_title：Clinical and experimental immunology

authors： Verhoeven GT,Van Haarst JM,De Wit HJ,Simons PJ,Hoogsteden HC,Drexhage HA

更新日期：2000-11-01 00:00:00

abstract：:We investigated the role of inflammatory cytokines in a mouse model of chronic Pseudomonas aeruginosa infection mimicking diffuse panbronchiolitis (DPB), and determined the effects of clarithromycin therapy on the production of these cytokines. The concentrations of IL-1beta, IL-2, IL-4, IL-5, interferon-gamma (IFN-ga...

journal_title：Clinical and experimental immunology

authors： Yanagihara K,Tomono K,Kuroki M,Kaneko Y,Sawai T,Ohno H,Miyazaki Y,Higashiyama Y,Maesaki S,Kadota J,Kohno S

更新日期：2000-10-01 00:00:00

abstract：:Increased serum cytokine levels have been reported in patients with autoimmune thyroid disease, but less is known about their levels in patients with Graves' ophthalmopathy (GO). It is not known whether GO is a cell-mediated or humoral autoimmune disease. We investigated whether serum cytokines are elevated in GO pati...

journal_title：Clinical and experimental immunology

authors： Wakelkamp IM,Gerding MN,Van Der Meer JW,Prummel MF,Wiersinga WM

更新日期：2000-09-01 00:00:00

abstract：:CD44 is an adhesion molecule involved in a wide range of cell-cell and cell-matrix interactions. The standard form of CD44 (CD44S) is a 85-90-kD glycoprotein, but alternative splicing of RNA encoding 10 variable exons (V1-V10) can give rise to many different CD44 variant protein isoforms of higher molecular weight. CD...

journal_title：Clinical and experimental immunology

authors： Takazoe K,Foti R,Tesch GH,Hurst LA,Lan HY,Atkins RC,Nikolic-Paterson DJ

更新日期：2000-09-01 00:00:00

abstract：:It is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible co...

journal_title：Clinical and experimental immunology

authors： Katoh N,Hirano S,Suehiro M,Ikenaga K,Yamashita T,Sugawara N,Yasuno H

更新日期：2000-08-01 00:00:00